The Dutch defender, on loan from Chelsea, suffered a thigh strain during the 1-1 draw with Midlands rivals Coventry and faces around a month on the sidelines.
Bruno Berner is the natural replacement at left-back but boss Sven-Goran Eriksson also has other options.
Kyle Naughton could switch sides while Ben Mee and Miguel Vitor can also play in that position.
Chris Weale is another fresh injury concern after the goalkeeper hurt his back in training. He will be monitored.
The Foxes will be looking for a return to winning ways in their quest for a play-off place having taken just one point from their last two games.
Source: PA
Source: PA