The 67-year-old said he did suffer with "some issues and short term memory loss" but denied mental health issues.
In a statement to Press Association Sport, Worthington said: "Further to speculation about my health in the last 24 hours I would like to make it clear that I have never been diagnosed with Alzheimer's disease or any other neurological disorder or illness."
In a statement on her Facebook page on Thursday, Worthington's daughter Kim-Malou Worthington had claimed her father was suffering from Alzheimer's.
The statement from Worthington continued: "I do have some issues with short term memory impairment but I have been assured this is not particularly unusual for a man of my age
"I continue to lead a full and active retirement."
Alzheimer's is the most common cause of dementia, symptoms of which include memory loss and difficulties with thinking, problem-solving or language.
Over the last 12 months, the families of England World Cup winners Martin Peters, Nobby Stiles and Ray Wilson have all spoken of the trio's struggles with the disease.
Halifax-born Worthington is regarded as one of the 'mavericks' of the era, alongside the likes of George Best, Stan Bowles, Rodney Marsh and Tony Currie
He released an autobiography 'One Hump or Two' which contained entertaining accounts from his playing days, as well as stories about his life off the pitch
A flamboyant striker, Worthington started his career at nearby Huddersfield in 1966 but also caught the eye at Leicester, Birmingham, Leeds, Sunderland, Southampton, Brighton and Tranmere
He was a target for Liverpool in the early 1970s but a proposed move collapsed because he failed his medical as a result of high blood pressure
Worthington, who played eight games and scored two goals England in 1974, also had loan spells in America with Tampa Bay Rowdies and Philadelphia Fury, and in Sweden with Mjallby, before shorter stints with lower league clubs in England, as well as Galway United in Ireland
He also managed Tranmere in the mid-1980s
Source : PA
Source: PA