But Roberto Di Matteo's squad have two games in hand on Leicester and a victory could prise open the title race.
Defender Michael Morrison, who came on against the Pirates, could deputise for Hobbs.
Captain Matt Oakley should be fit to travel with the squad after recovering from a groin injury that prevented him from completing the 90 minutes on Saturday.
However should Oakley miss out Tom Cleverley will hope to get a chance in midfield.
Dons could still be without Luke Howell and Luke Chadwick.
Howell is struggling with a hamstring strain and Chadwick faces a late fitness test following a similar injury.
The teams meet for only the second time in the Dons' history with the first clash between the two top teams coming on the opening day of the current campaign.
The Dons will be trying to narrow the 12-point gap between the sides and further secure their chances of automatic promotion from League One at the first time of asking.
Dons top scorer Aaron Wilbraham returned to the starting line-up in last week's 1-1 draw with Tranmere and is likely to retain his place despite pressure from Ali Gerba.
Sporting Life